at 9:30 PM JST / 2:30 PM CEST / 5:30 AM PDT
Joseph A. Loo
(University of California, Los Angeles, U.S.A.)
(Pacific Northwest National Laboratory, U.S.A.)
(Pasteur Institute, France)
(Christian-Albrechts-Universität zu Kiel, Germany)
(Kyoto University, Japan)
Nobuaki Takemori, organizer
(Ehime University, Japan)
Top-down proteomics, which enables large-scale analysis of proteoforms, is rapidly attracting interest among researchers in various life science fields. In this webinar, world-leading researchers in top-down proteomics and proteoform research will introduce their latest findings and discuss how top-down proteomics will be promoted in Japan.
What is proteoform analysis? Can’t bottom-up proteomics alone be used for analysis?
Dr. Ishihama (Kyoto University) will introduce proteoform research from the perspective of bottom-up proteomics and explain the importance of top-down proteomics in comprehensive proteoform analysis.
What technologies are needed to conduct top-down proteomics studies?
Dr. Tholey (CAU) will explain state-of-the-art mass spectrometry and intact protein separation techniques that enable top-down proteomics and present examples of in-depth proteoform analysis using top-down proteomics techniques.
How are proteoforms identified from top-down mass spectrometry data?
Dr. Tabb (Pasteur Institute) will introduce the principles of and required resources for top-down MS data analysis and will present examples of actual data analysis and explain how proteoforms are identified in an easy-to-understand manner.
What about analysis of entire protein complexes?
Top-down proteomics can even be combined with native mass spectrometry to analyze the entire structure of a protein complex. Dr. Zhou (PNNL) will present the principles of this newest technique, called native top-down proteomics, and its application to plant research.
What are the future prospects for this new and powerful proteomics research in the field of medicine?
Attempts to use top-down proteomics for human disease research have also begun. Dr. Loo (UCLA), a pioneer in this field, will tell us what top-down proteomics research has accomplished so far and what challenges lie ahead.
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|Identifying proteoforms from top-down MS/MS: is one search enough?|
|Dissecting unknown and heterogenous plant proteins by native top-down mass spectrometry|
Joseph A Loo
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This zoom webinar is free of charge and open all, including non-members!
A link to participate in the JPrOS pre-congress webinar will be sent to your registered e-mail address. If you do not receive the link on that day, please contact us.
For inquiries about the webinar: takemori(at)m.ehime-u.ac.jp